Best Weight Loss Medications Of 2025

Best Weight Loss Medications Of 2025

Below are several of the most popular telehealth platforms for getting weight loss medication prescriptions online. Choose the best fit for your goals and lifestyle.

We earn a commission from the offers on this page, which influences which offers are displayed and how and where the offers appear. Advertiser Disclosure.

BEST OVERALL

1

joinFridays

Get compounded Semaglutide & Tirzepatide

One single price every month, with everything included

One-on-one coaching & metabolic health support

9.9

Outstanding

Go to Remedy Meds

Highly rated

2

FellaHealth - Weight loss for men

Free personalized health coaching

Access to Semaglutide & Tirzepatide

One-on-one coaching & metabolic health support

9.5

Excellent

Go to FellaHealth

Frequently chosen

3

Delilah - Weight loss for women

Get compounded Semaglutide & Tirzepatide

Medication included in the cost

Complimentary lab work included in your plan

9.3

Excellent

Go to Delilah

4

Remedy Meds

Get compounded Semaglutide & Tirzepatide

Get compounded Semaglutide & Tirzepatide

Get compounded Semaglutide & Tirzepatide

9.8

Excellent

Go to Remedy Meds

5

MEDVI

Doctor-prescribed GLP-1 medications

Unlimited 24/7 support included

1:1 Personalized dietician coaching

9.0

Great

Go to MEDVI

Our partners provide compounded medications that have not undergone independent review or approval by the FDA for safety or effectiveness.

Calorie-managed diets and exercise have been the mainstay approach of commercial weight loss programs for decades. But as weight loss medications like Ozempic®, Wegovy® and others become household names, people trying to lose weight are exploring adding medications to their weight loss toolkit.

Are Weight Loss Medications Effective?

“Obesity is a condition that affects more than 40% of our adult population and when factoring in candidacy for medications, such as those with overweight and a weight-related condition, the numbers get even higher,” says Anthony Jay Millard, M.D., a board-certified obesity medicine physician at Northwestern Medicine in Chicago. He notes the need for an “all-hands-on-deck approach” with providers across the healthcare spectrum.

Many providers are familiar with the latest weight-loss medications, but not all individuals are candidates for these medications, says Dr. Millard.

Popular Weight Loss Medications

Ozempic®

Ozempic® is an FDA-approved medication for treating type 2 diabetes. Its active ingredient is semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist that acts like the GLP-1 hormone released in the digestive tract when eating. This weight-regulating hormone “signals fullness to the brain, delays stomach emptying and lowers blood sugar,” says Rekha Kumar, chief medical officer at the medically-assisted weight loss program, Found, and practicing endocrinologist in New York City.

The medication is available by prescription only and is used as a weekly injection to help with blood sugar management and help reduce the risk of a heart attack or stroke in people with type 2 diabetes. Since semaglutide has shown effectiveness in reducing body weight for those with overweight or obesity, Ozempic® may also aid in weight loss. However, Ozempic® itself is not FDA approved to treat weight loss alone in patients without a diagnosis of type 2 diabetes.

Wegovy®

Wegovy® is another injectable medication made with semaglutide (the active ingredient in Ozempic®). It’s approved by the FDA for weight management in people with a body mass index or BMI of 27 who have another weight-related condition, such as type 2 diabetes, or those with a BMI of 30 or higher.

Like Ozempic®, Wegovy® is also prescription only and taken once a week.

Saxenda®

Saxenda®, like Ozempic® and Wegovy®, is a GLP-1 receptor agonist, but it’s made with liraglutide (instead of semaglutide). The medication is also prescription-only and FDA-approved for the treatment of obesity in people aged 12 and older who weigh more than 132 pounds or adults with BMI of 30 or higher.

Liraglutide works by helping to decrease appetite and slow the emptying of the stomach, which causes feelings of fullness and leads to lower calorie intake.

Saxenda® is a daily injection, while Ozempic® and Wegovy® are weekly injections.

UNLIMITED 24/7 MESSAGING

Remedy Meds: Free 2-min quiz to qualify

UNLIMITED 24/7 MESSAGING

Remedy Meds: Free 2-min quiz to qualify

Weight Loss Medications vs. Fat Burning Pills

Weight loss medications and fat burning pills are vastly different. Fat burning pills and other “quick-fix” weight loss supplements are typically sold over the counter and are not regulated in the same way as weight loss medications. Unlike fat burning pills, weight loss medications require a prescription from a healthcare provider and have been studied extensively for their ability to promote weight management when combined with diet and lifestyle changes.

How to Choose the Best Weight Loss Medication for You

“It is critical that patients remember that these medications are not a magic bullet for weight loss and long-term weight management,” notes Dr. Millard. Nutrition, physical activity, stress and sleep are all critical parts of an optimal weight management plan, he explains, noting that the larger social environment plays a role, too.


With weight issues being so complicated, he points out, “if a provider is suggesting that these medications are a quick fix or only needed for short-term use, that would be a red flag that the chronic nature of obesity is not being considered.” If this occurs, he suggests you find a different provider.


Many people stay on weight loss medications for a few months while working on their diet and exercise routines. Others stay on them indefinitely. Regardless of what you decide medication-wise, exercise and nutrition are essential components of any healthy life, and even small changes can make a big difference over time.


Whether you’re interested in trying weight loss medication, mulling over the idea of joining a commercial weight loss plan or are interested in combining the two, your first stop should be your doctor’s office. Your doctor can discuss the pros and cons of starting medication and help choose the best weight loss medication plan for you.

UNLIMITED 24/7 MESSAGING

Remedy Meds: Free 2-min quiz to qualify

UNLIMITED 24/7 MESSAGING

Remedy Meds: Free 2-min quiz to qualify

joinFridays

Go to joinFridays

Get compounded Semaglutide & Tirzepatide

One single price every month, with everything included

One-on-one coaching & metabolic health support

1

9.9

Outstanding

BEST OVERALL

Fella Health - Weight loss for men

Go to FellaHealth

Free personalized health coaching

Access to Semaglutide & Tirzepatide

One-on-one coaching & metabolic health support

2

9.5

Excellent

Highly rated

Delilah - Weight loss for women

Go to Delilah

Get compounded Semaglutide & Tirzepatide

Medication included in the cost

Complimentary lab work included in your plan

3

9.3

Excellent

Frequently chosen

joinFridays

Go to joinFridays

Get compounded Semaglutide & Tirzepatide

Get compounded Semaglutide & Tirzepatide

Get compounded Semaglutide & Tirzepatide

4

9.8

Excellent

5

9.0

Great

MEDVI

Go to MEDVI

Doctor-prescribed GLP-1 medications

Unlimited 24/7 support included

1:1 Personalized dietician coaching

Copyright © 2025 CompareMD

All rights reserved.

Our goal is to provide answers to all of your questions so you can make a confident purchasing decision. We welcome your feedback, so please email us at service@comparemd.com with suggestions and questions.

Copyright © 2025 CompareMD

All rights reserved.

Our goal is to provide answers to all of your questions so you can make a confident purchasing decision. We welcome your feedback, so please email us at service@comparemd.com with suggestions and questions.

Copyright © 2025 CompareMD

All rights reserved.

Our goal is to provide answers to all of your questions so you can make a confident purchasing decision. We welcome your feedback, so please email us at service@comparemd.com with suggestions and questions.